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In SURPASS-2, tirzepatide was compared directly with semaglutide (another GLP-1 receptor agonist) in patients with type 2 diabetes, with participants continuing background metformin therapy as a requirement for enrollment
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Several ionic mechanisms such as non-selective cation channel, voltage-dependent potassium channel, and TRPC5 channel may be associated with activation of GLP-1R-induced electrophysiological effects (Figure 1A)
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