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These data reinforce the potential clinical benefits of long-term therapy for people living with obesity and pre-diabetes. While those taking 15 mg of tirzepatide lost the most weight, those taking 5 mg of tirzepatide lost 15.4 percent of their body weight, and those taking 10 mg lost 19.9 percent at week 176

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Semaglutide is the active ingredient in these medications

We outline major translational and biological challenges, identify key gaps for future research and discuss emerging approaches aimed at achieving durable and scalable obesity treatment

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If they get too hot, the chemical bonds that hold the molecule in its specific shape can begin to break down