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For people with a history of dieting or disordered eating, however, reduced appetite may also raise concerns about maintaining adequate nutrition or navigating past challenges with food

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456 The I-SPY 2 umbrella trial precisely matches multiple novel agents or combination therapies to breast cancer molecular subtypes, enabling rapid assessment of early efficacy signals and adaptive optimization, thereby accelerating the development of precision treatments for high-risk breast cancer patients (NCT01042379)

So I love how you outline that in the book and explain all that in the book