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Very recently, direct-immunofluorescence microscopy of rat lower hindlimb muscles revealed that with aging, extracellular matrix (ECM)-bound HGF undergoes tyrosine residue (Y) nitration, as visualized by anti-nitrated Y-HGF monoclonal antibodies (mAbs, rat clones 3A11C6 and 6B82C3 raised in-house) in experiments employing three age-groups of young (2-month-old), adult (10-month-old), and old rats (20-month-old) 32
New England Journal of Medicine , 390(8), 712-724
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GLP-1 reduces appetite and slows stomach emptying
It supports appetite regulation, which may contribute to metabolic health, but it does not directly cause weight loss
This conformational restriction prevents the peptide from adopting flexible substrate orientations that proteases require for efficient cleavage
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