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Since the treatment algorithm put forth by the ADA says always start with metformin first, some professionals and people with diabetes are asking, why start with metformin and not with one or both of these two classes of medications

4 Metabolic and energy-balance peptides beyond the incretin paradigm While incretin biology has dominated metabolic drug development over the past decade, incretins represent only a subset of the endogenous peptide networks governing energy balance

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### Standard Reconstitution Ratios | Vial Size | BAC Water Added | Concentration | Dose 1mg = | Dose 2mg = | Dose 4mg = | |-----------|-----------------|---------------|------------|------------|------------| | **6mg** | 1.0mL | 6mg/mL | 0.17mL (17 units) | 0.33mL (33 units) | 0.67mL (67 units) | | **6mg** | 2.0mL | 3mg/mL | 0.33mL (33 units) | 0.67mL (67 units) | 1.33mL (133 units)* | | **10mg** | 1.0mL | 10mg/mL | 0.10mL (10 units) | 0.20mL (20 units) | 0.40mL (40 units) | | **10mg** | 2.0mL | 5mg/mL | 0.20mL (20 units) | 0.40mL (40 units) | 0.80mL (80 units) | | **12mg** | 2.0mL | 6mg/mL | 0.17mL (17 units) | 0.33mL (33 units) | 0.67mL (67 units) | | **12mg** | 3.0mL | 4mg/mL | 0.25mL (25 units) | 0.50mL (50 units) | 1.0mL (100 units) | | **20mg** | 2.0mL | 10mg/mL | 0.10mL (10 units) | 0.20mL (20 units) | 0.40mL (40 units) | | **20mg** | 4.0mL | 5mg/mL | 0.20mL (20 units) | 0.40mL (40 units) | 0.80mL (80 units) | | **24mg** | 3.0mL | 8mg/mL | 0.125mL (12.5 units) | 0.25mL (25 units) | 0.50mL (50 units) | | **30mg** | 3.0mL | 10mg/mL | 0.10mL (10 units) | 0.20mL (20 units) | 0.40mL (40 units) | | **30mg** | 6.0mL | 5mg/mL | 0.20mL (20 units) | 0.40mL (40 units) | 0.80mL (80 units) | | **40mg** | 4.0mL | 10mg/mL | 0.10mL (10 units) | 0.20mL (20 units) | 0.40mL (40 units) | | **50mg** | 5.0mL | 10mg/mL | 0.10mL (10 units) | 0.20mL (20 units) | 0.40mL (40 units) | | **60mg** | 6.0mL | 10mg/mL | 0.10mL (10 units) | 0.20mL (20 units) | 0.40mL (40 units) | *Units over 100 require a 2mL syringe

Allow 48 to 72 hours for process