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Dr Paramesh Shamanna #Diabetes #Type2Diabetes #GLP1 #Tirzepatide #Semaglutide #Obesity #MetabolicHealth #Endocrinology #CGM #DiabetesRemission #Cardiometabolic To view or add a comment, sign in More Relevant Posts Day 49 / 365 Medicine of the Day: Rosuvastatin Drug Class: Statin (HMG-CoA Reductase Inhibitor) Lipid-lowering agent Indications / Uses: Hypercholesterolemia ( LDL-C) Mixed dyslipidemia Hypertriglyceridemia Prevention of cardiovascular events (MI, stroke) Familial hypercholesterolemia Mechanism of Action (MOA): Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis Cholesterol production in liver LDL cholesterol & triglycerides HDL cholesterol LDL receptor expression increased LDL clearance Dose: Usual starting: 1020 mg once daily Maintenance: 540 mg once daily Severe hypercholesterolemia: up to 40 mg/day Renal impairment: lower starting dose recommended Adverse Effects: Myalgia / muscle pain Elevated liver enzymes Headache Nausea Risk of rhabdomyolysis (rare) Slight increase in blood glucose Drug Interactions: Cyclosporine rosuvastatin levels Gemfibrozil risk of myopathy Warfarin anticoagulant effect Antacids (Al/Mg) absorption Protease inhibitors statin toxicity risk Contraindications: Active liver disease Pregnancy Breastfeeding Hypersensitivity Clinical Pearl: Rosuvastatin is one of the most potent statins with strong LDL-lowering ability and proven cardiovascular risk reduction, often effective at lower doses compared to other statins

To our surprise we discovered that only a single GCG encodes a GLP-1 peptide with two functions, one in venom and the other in the gut

2 Literature search strategy This narrative review aimed to synthesize current mechanistic and clinical evidence regarding tirzepatide in obesity-related OSAS

Schneider-Helmert's double-blind study showed reduced sleep latency in the DSIP group compared to placebo (Schneider-Helmert, 1992)

J Clin Nurs Res (2022) 6:6775

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