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CD38 and regulation of the immune response cells in cancer
280 The accumulation of unfolded or misfolded proteins triggers the unfolded protein response (UPR), an adaptive signaling network coordinated by the endoplasmic reticulum sensors IRE1, PERK, and ATF6, which functions to restore proteostasis and maintain cellular homeostasis
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This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]
Exclusion criteria included conditions affecting blood glucose metabolism
The loss of pigment in hair shafts because of decreased melanocyte function is typically known as graying, or going gray, although the exact cellular and molecular mechanisms are not yet completely understood
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