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This rapid signal, mediated by neuropod cell release of glutamate onto VANs, provides nearly instantaneous spatial and temporal information on a meal, which can then be followed by more traditional gut peptidevagal afferent signaling pathways outlined below 95,96

It responds to the patients physiology rather than forcing the patient to fit a rigid plan

However, until now weight reduction induced by modified fasting therapy has not been proved to be effective for long-term weight management

Acknowledgments We gratefully acknowledge the authors and participants of all public databases from which we used data

Patients with pre-existing tachyarrhythmias , particularly atrial fibrillation or atrial flutter, should be evaluated carefully before initiating GLP-1 therapy