Recent studies by the Gastroparesis Clinical Research Consortium (GCRC) in the USA, where full thickness gastric biopsies have been obtained in individuals with refractory gastroparesis, have yielded important insights relating to the pathophysiology of diabetic gastroparesis [11]
10 When coadministered with a TZD, exenatide was associated with an 11% increased risk of hypoglycemia, compared with 7% for placebo
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These compounds are diverse and include terpenoids, alkaloids, flavonoids, etc
Animal studies and limited human trials suggest this can produce a mild GLP-1 response, though the effect size remains significantly smaller than pharmaceutical GLP-1 agonists