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On one hand, IBD can lead to dysregulation of adipokines, shifting the balance towards a pro-inflammatory state, on the other hand obesity and higher BMI are associated with higher risk of developing IBD and worse clinical outcomes, particularly for UC
It has potent effects of antioxidant, anti-inflammatory, anti-angiogenesis, and anti-cancer [131]
Newer GLP-1 formulations delivered weight-loss numbers rivaling those of bariatric surgery, with more than half of semaglutide trial participants losing at least 15% of their body weight over 68 weeks
Experimental and clinical data suggest increased AMPK activity, improved insulin sensitivity, and modulation of mTOR-related signaling, patterns that overlap with metabolic adaptations observed during caloric restriction [11,12]
Differentiation 84(1):416 Uenaka R, Kuwajima M, Ono A, Matsuzawa Y, Hayakawa J, Inohara N, Kagawa Y, Ohta S (1996) Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice
