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Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located calcium-sensing receptors

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ABMR cells exhibited lower OXPHOS, citrate (TCA cycle), glutathione metabolism, and vitamin A and biosynthetic machinery (valine, leucine, and isoleucine degradation

Moreover, compromised mitochondrial signaling reduces energy production and elevates ROS, which subsequently inflict damage upon endothelial cells and inhibit NO synthesis, thereby exacerbating the muscle-vascular dysfunction (25)

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