Participants were on background therapy with one to three oral diabetes medications (metformin, a sulfonylurea or an SGLT2 inhibitor)
a STEP dose-ranging study showed that participants on 2.4 mg lost nearly twice as much weight as those on 1.0 mg, independent of baseline body weight (Wilding et al., 2021)
Who May Be a Good Candidate for Tirzepatide
The Pillars of Recovery Generally speaking, recovery from any stage or phase of Adrenal Fatigue Syndrome will have the Adrenal Fatigue diet and decreasing stress as its cornerstone
The mechanism: tirzepatide lowers insulin resistance, and high insulin secretion is regarded as a driver of follicle miniaturization, partly through stronger androgen signaling and more DHT production
The rate of loss slowed somewhat in the later weeks as a new energy balance was approached, but the trajectory had not leveled off by week 48