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Why this dose+ Higher is not known to work better, and no human dose-response curve exists to justify going past this
Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)
One strategy currently being evaluated in early-phase clinical trials focuses on mitochondrial glutaminase (GLS1), an enzyme responsible for converting glutamine to glutamate (e.g., CB-839 from Calithera Biosciences) 40
Stress and telomere shortening: insights from cellular mechanisms [J]
However, there are not yet any firm dosing recommendations in therapeutic contexts
Both biomarkers were significantly increased in the treatment group and remained unaffected in patients receiving placebo
