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Su mecanismo de accin abarca mltiples niveles del sistema regulador del apetito y el metabolismo energtico: A nivel central , semaglutida se une a los receptores GLP-1R localizados en reas especficas del hipotlamo como el ncleo arcuato, lo cual reduce el impulso de hambre y promueve la saciedad mediante la activacin de neuronas anorexignicas (POMC/CART) y la inhibicin de neuronas orexignicas (AgRP/NPY)

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Putting agonist activity at all three receptors into a single molecule is a relatively new pharmacology, and retatrutide is the lead compound exploring it