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Tell patients to look out for increasing redness, warmth, or drainage from the injection sites and contact their healthcare provider immediately if they notice these signs

Ann Neurol 1994;36:680-1

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This implies that the activated receptor is primed to activate multiple rounds of G protein coupling following dissociation of the initial interacting transducer protein, and this is proposed to contribute to the sustained cAMP signalling following activation of class B1 GPCRs