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On the contrary, a recent clinical trial conducted on humans (male) found that taking 10mg of melanotan 2 before bedtime for three months reduced insulin sensitivity by 12%[5]
doi:10.1056/NEJMoa2410819 16
It is therefore not certain that sufficient metformin reaches skeletal muscle to mediate the aforementioned effects directly within myocytes
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However, long-term, unabated inflammation can lead to chronic disease
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