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Dose reduction typically resolves these effects within a few days
Energy-dispersive X-ray spectroscopy (EDX) was performed on a Tecnai G2 F30 TEM (Philips, Eindhoven, Netherlands) equipped with a 300 kV acceleration voltage for analyzing the elemental composition of the samples
Clinical Update 10/04/2022 Choline for Cognitive Function
Semaglutide allows a five-day catch-up window, tirzepatide allows four days, and daily oral options are as simple as skipping and resuming the next morning
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Secondary Outcome: Secondary Outcomes: Changes in waist circumference, body fat, body lean mass, and metabolic risk factors including levels of plasma glucose, insulin sensitivity, serum lipids, and blood pressure Statistical Analysis Full details previously published 2 and can also be found in the STEP group statistical analysis plan at NEJM.org Statistical analysis approach sought strong control for type I error All endpoints addressing intervention efficacy were analyzed using intention-to-treat approach All endpoints addressing intervention safety were analyzed using per-protocol approach Efficacy endpoints analyzed using 2 estimands Treatment Policy Estimand: intention to treat analysis
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