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The overlap strategy is reserved for patients with documented rapid weight regain during prior treatment gaps

Lancet 392(10157):15191529 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB (2016) LEADER Steering Committee

Virus infection and replication cause delayed interferon response, severe inflammatory monocyte macrophage and neutrophil infiltration and uncontrolled flood of proinflammatory cytokines and chemokines [22]

However, the SGLT2i treated cohort were less likely to develop heart failure (RR 0.44 [95% CI 0.23, 0.83] p =0.0092), CKD (RR 0.49 [95% CI 0.28, 0.86] p =0.0118) and be hospitalised for any cause (RR 0.59 [95% CI 0.46, 0.76] p 0.0001) when compared with the GLP-1 RA treated cohort

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The native peptide 1 had an IPGTT curve similar to the vehicle as expected from previous studies