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The goal is not broad suppression but precise recalibration
TEER measures the net flux of all ions (cations and anions) across the epithelium and reflects the contribution of the paracellular resistance (R para ) that reflects the resistance of the TJs, the transcellular resistance (R trans ) that reflects the resistance to ions of the apical (R api ) and basolateral (R bas ) membranes and finally the sub-epithelial resistance (R sub )
This combination becomes particularly important for men on TRT, as testosterone therapy can accelerate calcium metabolism
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Dnmts and Tet enzymes mainly maintain DNA methylation and demethylation patterns 41
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