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4,41,42 The 52-week phase 3 open-labeled RCT (PIONEER-2) studied 821 T2D patients needing a second agent after metformin and demonstrated that 14 mg of once-daily oral semaglutide was superior to 25 mg of once-daily empagliflozin, in respect of HbA1c reduction
The latter has safety and efficacy concerns
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The trial lasted slightly longer than one year
Many individuals face emotional challenges when trying to lose weight, including feelings of frustration or discouragement
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