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In a head-to-head study (SURPASS-2), Mounjaro topped Ozempic (1 mg semaglutide), showing it was more effective in helping patients keep their blood sugar levels in check and lose weight

Additionally, the N-terminal extension may partially shield protease-sensitive sites on the IGF-1 backbone from insulin-degrading enzyme (IDE) and other endopeptidases

Moderate, steady fat loss with consistent protein intake consistently produces better body composition outcomes than rapid loss with inadequate protein even if the scale moves faster in the short term

What does the clinical evidence say about GLP-1 and pancreatic inflammation

Pediatr Nephrol 39:28452860

Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity - a non-randomized three-armed controlled trial