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Proc Natl Acad Sci USA 1983
Clinical trials at therapeutic doses (5 to 15 mg) showed mean body weight reductions of 15% to over 20% over 72 weeks in participants with obesity, depending on dose
2025;4(4):e70048
2018 Dec;34(6):281-289
Therefore, the clearance of senescent cells through apoptosis is one of the proposed mechanisms to reduce the burden imposed by the presence of senescent cells and in consequence, prevent age-related diseases and ultimately revert aging 3
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