While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists
The main paper tested a limited group of hormones, not every possible biological effect
Use of glucagon-like peptide-1 receptor agonists in eating disorder populations
Obesity and cancer mechanisms: tumor microenvironment and inflammation
What follows is extrapolated from published rat and mouse studies, where tissue repair endpoints were measured at specific time points
Counteracted low NO-level in inferior caval vein and particular gene expression (i.e