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Similarly, Importantly, there is no evidence that these ingredients are effective when delivered through the skin, and it remains unclear whether they can penetrate the skin in sufficient amounts to produce physiological effects

Knudsen, L.B., Lau, J

Based on the known class profile of GLP-1 and glucagon receptor agonists, the following additional risks are relevant: Pancreatitis: Severe and persistent abdominal pain, particularly if it radiates to the back and is accompanied by vomiting, may indicate pancreatitis

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9.4%), decreased appetite (5.8%, 12.3%, 17.1% vs