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This coordinated engagement across the pancreas, brain, gut, liver, and adipose tissue underlies the mechanistic rationale for dual GLP-1/GIP receptor agonists, and explains why they have been described as super GLP-1RAs, reflecting genuine potentiation of GLP-1 action by GIP receptor agonist co-activation

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Twenty-eight of them were judged to have moderate depression, and 43 had severe depression

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(A) After pretreatment with GLP-1 of different concentration and induction by H 2 O 2 , cell viability was assessed with MTT assay, n = 6

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