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A 168 , 3539 (1992)

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When tested as a once-daily injection in single and multiple doses varying up to 0.18 mg in healthy normal to overweight volunteers, gastrointestinal adverse events (nausea, diarrhoea, constipation, vomiting) were encountered, but the drug was described as well tolerated

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Rosenstock J, Nino A, Soffer J, et al

Most people get the recommended dietary allowance of B12 (2.4 micrograms for adults, more for pregnant or lactating women and the elderly) through their daily intake of food