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Adherence, dose tolerance, baseline metabolism, and lifestyle all influence outcomes

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Frias JP, Bonora E, Nevarez Ruiz L, Li YG, Yu Z, Milicevic Z, et al

Mitochondrial function also feeds back on the degradative pathway of this circuit, because mitochondrial respiratory defects can impair lysosome competence and endolysosomal trafficking, linking primary mitochondrial dysfunction to reduced clearance capacity and exaggerated inflammatory programs (65)