Because metformin and GLP-1 drugs influence separate physiological systems, they provide complementary rather than redundant effects on body weight and blood sugar
But so far, CookUnity looks to be a big exception
Microdosing GLP-1/GIP therapies may help: Improve glycemic control, stable blood glucose levels, and blood pressure support Reduction in visceral fat and waist circumference Potential improvements in lipid profiles Reduce systemic inflammation markers associated with cardiometabolic disease Glycine amino acid that supports protein synthesis, endothelial function, and insulin sensitivity Reduce cardiovascular risk factors such as insulin resistance and central adiposity Whats Included Monthly compounded tirzepatide + glycine (Up to 3mg/week) or 2ml tirzepatide with B12 every 2 months with labs Personalized microdosing protocol Ongoing provider oversight with labs every six months This is not an FDA-approved microdosing regimen
The only bad thing is they dont have brand name medications (Ozempic, Wegovy, etc) so if thats what youre looking for, Id check out Hims & Hers or WeightWatchers Clinic
On the other hand, the researchers also pointed out a number of limitations of the meta-analysis
The rate was highest in the first month