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The hepatic bile acid synthesis is tightly regulated by negative feedback mechanisms (199) and by transforming primary into secondary bile acid species, the intestinal microbiota strongly affects bile acid metabolism (200)
Consolidation of gains
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These medications are not recommended in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
Canagliflozin has been trialed in a phase IIb study in overweight and obese subjects without T2D
Roche, M., Rondeau, P., Singh, N
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