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Always prioritise evidence-based treatments recommended by your healthcare team
This was attributed to spermidines ability to activate mitophagy and autophagy, helping maintain mitochondrial quality and preventing the accumulation of damaged mitochondria in heart tissue (Reference Eisenberg, Abdellatif and Schroeder80)
The primary concerns are the potential for increased stomach irritation and the fact that your pain relief might take longer to arrive due to slowed digestion
Sleep-related observations tend to be reported earliest
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