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Recently, we found that semaglutide therapy post-stroke can prevent ischemia-induced neurotoxicity and normalize neurogenesis and proliferation of stem cells in the brain via inhibition of p38 MAPK/MKK/c-Jun activity, regulation of Bcl-2/Bax pathways, and C-raf/ERK/caspase-3, restoration of insulin signaling sensitivity, and normalization of the ERK1 and IRS1 pathways (120)
The peptide works particularly well when combined with other regenerative approaches or when administered soon after injury
2016;7: e142
A phase 3 trial of lanifibranor in patients with NASH and stage 23 fibrosis (NATiV3 trial) is currently ongoing
There was no plateau, and in fact it appears longer term trials will probably easily clear 20% weight loss, especially if metformin and/or SGLT2i medications are added on as these can both add another 2-3% extra weight loss when combined with a GLP-1 medication
If not, it remains an area to watch and perhaps participate in trials
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