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Evidence has demonstrated that iron deposition occurs in the brains of migraine patients ( Topiramate has been proposed as a migraine preventive medication because it inhibits ferroptosis via the glutathione peroxidase 4 (GPX4), GSH, and cystine/glutamate antiporter (System Xc-)
Nature 406, 775781
Schaffer SW, Ballard C, Azuma J
Recycling: Once glutathione does its job and neutralizes a free radical, it becomes "oxidized" or used up
Most treatments target one mechanism
By transporting long-chain fatty acids into the mitochondria, it facilitates the production of ATP (adenosine triphosphate) - the primary energy currency of the human body
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