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These changes typically peak within the first hour and return to baseline within 12 hours
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The confirmatory secondary endpoints included the change in the 6-min walking distance, a hierarchical composite of death and heart failure events
There is an ongoing phase 2/3 randomised, double-blind, placebo-controlled trial (NCT06126315) of the biological and clinical effects of acetyl-l-carnitine planning to recruit ~250 patients [88]