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In this study, we identified an elevated lipid metabolism in GRN -deficient hiPSCs and hiPSC-derived microglia cells
Doi: Walton NM, Shin R, Tajinda K, Heusner CL, Kogan JH, Miyake S, Chen Q, Tamura K, Matsumoto M (2012) Adult neurogenesis transiently generates oxidative stress
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In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau