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These medications, hailed for their ability to promote weight loss and stabilize blood sugar levels, have garnered widespread attention and acclaim

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Having trouble losing weight or gaining belly fat can be a sign of diabetic issues

However, FDA prescribing information recommends considering discontinuation for sustained significant increases in resting heart rate, and patients with persistent palpitations or heart rate above 100 bpm should consult their healthcare provider

The Journal of clinical investigation 112 , 608618, doi: 10.1172/JCI17305 (2003)

One important unresolved issue is the limited evidence regarding concomitant use of SGLT2 inhibitors and GLP-1 receptor agonists, a gap also acknowledged in European Society of Cardiology guidelines and Current guidelines prioritize SGLT2 inhibitors in patients with T2DM who have HF, chronic kidney disease, or elevated cardiovascular risk, while GLP-1 receptor agonists are emphasized for patients with obesity or established atherosclerotic cardiovascular disease [7]