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much lower at community doses Vomiting up to 36% at high doses Diarrhea 23-26% Constipation 17-19% Fatigue 11-13% Pancreatitis risk trials flagged severe abdominal pain for discontinuation and evaluation Gallbladder issues rapid weight loss increases gallstone risk Thyroid C-cell tumors same boxed warning as semaglutide (animal studies) GI side effects were more intense than semaglutide in trial data due to the dual mechanism

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Furthermore, the rather long distance of 5.8 between the SG2 atom of GSH and the OG atom of Ser20 residue suggests that the H-site bound GSH reacts with G-site bound GSH rather than the active site cysteine residue

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Scenario analyses We performed a number of scenario analyses

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Immediately after the alcohol or water administration, rats were placed in the chambers and after a 20-minute delay (allowing for blood and brain alcohol levels to rise and assessment to occur in the ascending limb of the alcohol curve: Quertemont et al

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