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Pancreatitis and pancreatic cancer were reported in some studies but not in large CVOTs with relatively long duration of follow-up
Curr Rheumatol Rep
Many experts believe this is often due to rapid weight loss and nutritional stress , rather than the medication itself
Propanediol is an all-star ingredient
Pivotal data: STEP-1 (Wilding et al., NEJM 2021) reported 14.9 percent body-weight reduction at 2.4 mg weekly over 68 weeks, and SELECT (Lincoff et al., NEJM 2023) was the first demonstration that a GLP-1 agonist reduces cardiovascular events in a population without diabetes (20 percent MACE reduction)
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