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While weight loss is often beneficial for health, it must be closely monitored in patients with multiple chronic conditions, especially when powerful medications are involved

If youre on a lower dose, discuss with your InstaClinic provider about safely increasing it

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In a 10-week clinical trial, a daily dose of 20 mg oral semaglutide achieved a steady-state plasma concentration of 30 nM, and when daily dose of oral semaglutide was increased to 40 mg, the semaglutide plasma concentration reached about 60 nM (102), which was over a thousand times higher than the EC50 of semaglutide for GLP-1R activation (95)

GLP-1 is made in the intestinal tract in response to the food you eat

Oct 2018;50(8):e13064