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This means that it could be difficult to tell if youre having a Crohns flare-up or if youre experiencing the side effects of semaglutide

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Moreover, the possibility of unexpected fluctuations in blood sugar levels raises significant concerns since both drugs interact with metabolic processes , albeit in fundamentally different ways

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Additionally, GLP-1 RAs should be considered in overweight or obese patients to reduce weight (class IIa, level B)

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Urinary tract infections (UTIs) are not specifically associated with GLP-1 medications in clinical trials, unlike SGLT2 inhibitors which do increase UTI risk

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The risk of hypoglycemia with DPP-4 inhibitors is low given their GLP-1 mediated glucose dependent mechanism of action

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Annual Review of Biophysics, 40, 169-186

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