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Careful dose escalation (extending the interval at each dose level) may be warranted Polypharmacy risk: Fibromyalgia patients often take multiple medications (SNRIs, anticonvulsants, muscle relaxants, sleep aids)

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Depression treatment might require slightly higher doses, with some people needing 20mg daily for optimal results

By delivering medication directly to the inflamed nerves, ESIs aim to reduce inflammation and block pain signals, thereby decreasing your pain level

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As all major obesity guidelines emphasize, lifestyle-based behavioral therapy remains the first-line foundation of care, with pharmacotherapy used as an adjunct rather than a replacement [35,36,37]