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doi: 10.1093/jnci/dji375 10 HuxleyRAnsary-MoghaddamABerrington De GonzlezABarziFWoodwardM
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Transcriptional mode of action is constitutive : ERRs occupy their DNA response elements (ERRE, 5'-TNAAGGTCA-3') and recruit transcriptional machinery even in the absence of ligand
Some patients report improvement in energy levels within several weeks of maintaining a stable dose, while others may experience longer periods of adaptation
The peptide is associated with changes in the hypothalamic-pituitary-adrenal axis, and this may play role in suicidal patients with major depressive disorder with altered DSIP-like immunoreactivity levels
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