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Despite the decrease of mtDNA content, hepatic COX lll mRNA level and COX activities and SDH activities were not altered significantly, implying that the change of mtDNA contents did not damage the mitochondrial gene transcription and mitochondrial function dramatically

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Long-Chain acylcarnitines decrease the phosphorylation of the insulin receptor at Tyr1151 through a PTP1B-Dependent mechanism

If so, these may be signs of a vitamin B12 deficiency

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