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they are also present in the brain, including regions affected by neurodegenerative diseases
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The study authors stated, No major safety concerns have arisen to date. Semaglutide Effectiveness Study reviews conducted in 2022 report that participants taking semaglutide lost between 5% and 20% of their body weight
The 20-30 hour half-life means the peptide still distributes systemically regardless of site, so any local-only effect is partial at best
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In human studies, exenatide (GLP1-agonist) showed a fetal-to-maternal peptide concentration ratio of 0.017 in ex vivo human placental perfusion in a single placenta
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