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In the TME, stimulated by signals such as TLR, B cell activating factor (BAFF), and B cell receptor (BCR), the glycolytic flux of Bregs increases, and is highly infiltrated in the TME
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Right now, we do not have any approved ways to impede the course of the disease
However, runners, who typically need more fluids than non-athletes due to intense physical exertion, should continue prioritizing hydration and not assume they can reduce their water intake even if their weight goes down
doi: 10.1038/s41419-019-2064-5 43 ManciasJDWangXGygiSPHarperJWKimmelmanAC
The delayed gastric emptying effect also has practical implications for medication absorption
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