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However, Ad vectors may trigger severe host reactions, including causing patient death during the first phase of gene therapy clinical trials [63]
The most commonly reported adverse effects in these trials were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the broader class of GLP-1 receptor agonists
Blue Cross Blue Shield of Massachusetts had one of its worst financial results in its history in 2025, underscoring the turbulence and disruption caused by ever-rising health care costs
Current trials also exclude people with diabetes, recent heart problems, and eating disorders, which may indicate future contraindications once approved
Both of those are brand-name semaglutide manufactured at scale by Novo Nordisk
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