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Each dose increase brings a temporary flare

Additionally, curcumin accelerates wound repair by promoting fibroblast proliferation, collagen synthesis, epithelialization, and vascularization while mitigating oxidative stress

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PDE5 inhibitors such as sildenafil and tadalafil generally exhibit better tolerability but can cause headache, flushing, dizziness, and visual disturbances due to partial inhibition of PDE6 in the retina (Wallis, 1999