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Oxidative Damage and Antioxidant Defense in Ferroptosis
Most melanotic macules are congenital, affect Caucasian individuals, may be single or multiple, have a diameter varying between 0.3cm and 3cm, tend to grow in proportion to the body growth, and are unrelated to any systemic condition.2,4 Their clinical features are not yet well-defined.1,2 The etiology of the disease still remains uncertain, but it is suggested that congenital cases may represent melanocyte hamartomas.2 Histology of the described cases of lingual melanotic macule reveals increased melanin in the basal cell layer, some pigment-laden macrophages in the dermis, normal number of melanocytes with no or a slight increase of melanin in their interior and variable degrees of hyperkeratosis.2 There are no nests of melanocytes, atypia, or alterations in the lingual tissue, and, in some cases, slight elongation of the epithelial ridges has been described.2 Also, according to Dohil et al., no similar histopathological alteration was identified in the non-affected lingual tissue.2 Our patient is an adult woman, which is uncommon when compared to other cases described
But the existing data, combined with what we know about GLP-1 receptor pharmacology, allows for some reasonable projections about what to expect over extended treatment periods
IGF-1 is the primary mediator of GHs downstream effects in tissue, muscle, bone, and skin
What do we know about semaglutide side effects
If the thought of self-injecting makes you nervous, ShedRx is one of the few clinics that offers alternatives like oral drops and lozenges, though its important to keep in mind that these are not FDA approved and their safety and efficacy cannot be guaranteed
