Orforglipron Compared With Dapagliflozin in Adults With Type 2 Diabetes and Inadequate Glycaemic Control With Metformin (ACHIEVE-2): A Multicentre, Randomised, Non-Inferiority, Open-Label, Phase 3 Trial
Barzilai cautions that GLP-1 receptor agonists are not a cure-all
The REWIND cardiovascular outcome trial also revealed that dulaglutide administration resulted in inferior ocular outcomes, leading to an increased need for interventions such as photocoagulation, anti-vascular endothelial growth factor (VEGF) therapy, or vitrectomy compared to placebo recipients [38]
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While the GLP peptides have been extensively studied, there are potential side effects and risks of taking these medications for weight loss
Many pharmacy benefit managers (PBMs) have implemented edits that flag or deny compounded GLP-1 claims automatically, requiring manual overrides or appeals