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Potential Side Effects of GLP-1 Medications Many people taking GLP-1 medications notice physical changes that can affect how they move and feel, including: Fatigue or decreased endurance Muscle weakness or loss of lean mass Joint stiffness or tendon discomfort Slower metabolism Balance changes or increased fall risk Digestive symptoms such as nausea or constipation These side effects dont mean you need to stop your medication but they do highlight the importance of maintaining movement, strength, and balance throughout your weight loss journey

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doi: 10.1038/s41586-020-2317-6, 104 SelleyM

Most standard supplements do not interact significantly with berberine or tirzepatide

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