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For instance, in IBS-C, a lower diurnal amplitude of phase III MMC activity fronts and impaired vagal cholinergic function are more pronounced, whereas in IBS-D repetitive and rapidly propagated bursts of contractions during phase II MMC, a shift toward sympathetic dominance and reduced vagal activity have been demonstrated [18-22]

It is one of the most common pigmented lesions of the lip, almost always harmless, and most often appears on the lower lip

[2] [3] It belongs to a novel class of agents known as triple hormone receptor agonists , meaning it simultaneously activates three distinct receptors involved in appetite regulation and energy metabolism: GLP-1 (glucagon-like peptide-1) receptor reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) receptor enhances insulin secretion and, based on preclinical and early clinical evidence, may contribute to improved fat metabolism Glucagon receptor preclinical and early clinical data suggest activation of this receptor may increase energy expenditure and promote fat breakdown (lipolysis), though the precise contribution in humans is still being characterised This triple-action mechanism distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 receptor agonist)

In contrast, Bambini-Junior et al